Morbus Hansen (Hanseniasis, Leprosy, Leprosy) is an infectious disease of chronic nature, caused by Mycobacterium leprae attacks the nerves tepid primary and secondary attack the skin, muscle RES upper respiratory tract, eyes and testes.
Pathophysiology
The entry of germs in the body can go through several possibilities, among others can be through non-intact skin, respiratory or digestive tract. Upon entry into the body, namely the prediction germ cells toward the place Schewann on peripheral nerve ..
In the germ cells proliferate, cell rupture and then infect others atu Schwann cells into the skin depending on the degree of immunity sufferer. At high immunity will occur tuberculoid type of leprosy, while in the low immunity will occur lepromatus type.
CLINICAL SYMPTOMS
The main complaint is usually as a result of peripheral nerve disorders, which in this case can be spots on the skin numbness, heavy, tingling, weakness of muscles and dry skin disorders due to spending the sweat glands.
Clinical symptoms that occur may include abnormalities in peripheral nerve, skin, hair, muscles, bones, eyes and testes.
1. Abnormalities in peripheral nerve
Abnormalities that occur may include thickening or tenderness due proseskeradangan fibrotic reaction.
The occurrence of peripheral nerves, especially on the trip, close to the surface of the skin al.: Nulnaris mgnus, n. Perouneus lateralis and n. Median.
2. Abnormalities of the skin
Abnormalities that occur may include numbness or macular spots anastetika, nodules, ulcers, ichtiosis, thickening and facies Leonina ear lobe.
3. Abnormalities in hair
Hair loss that occurs is usually limited to mukula or on eyebrows (madarosis)
4. Abnormalities in muscle
The disorder can be a disuse atrophy of muscles that dienervasi by the damaged peripheral nerve al: atrophy of the thenar, hypothenar, M.interosei, M.lumbricalis.
Paralysis of the muscles followed by stiffness of the joints resulting in Claw Hand, foot and drop hand drop.
5. Abnormalities in bone
Can be either osteomyelitis resulting in mutilation.
Can occur res orbsi on bone, especially in the fingers so that the bent tip retracts and is referred to as telescopic finger.
6. Abnormalities in the eye.
Disorders of the eye is often caused by paralysis of m. orbiculris oculi resulting lagopthalmus or eyes can not dipejamkan so that the eye becomes dry due to occur that may progress to keratitis kronea ulcer, iritis, and ended iridosi klitis blindness.
7. Abnormalities of the testis
Can occur orchitis or inflammation of the testes and ends menjaadi atrophy. Testicular atrophy, which results ginekomasti.
Pathophysiology
The entry of germs in the body can go through several possibilities, among others can be through non-intact skin, respiratory or digestive tract. Upon entry into the body, namely the prediction germ cells toward the place Schewann on peripheral nerve ..
In the germ cells proliferate, cell rupture and then infect others atu Schwann cells into the skin depending on the degree of immunity sufferer. At high immunity will occur tuberculoid type of leprosy, while in the low immunity will occur lepromatus type.
CLINICAL SYMPTOMS
The main complaint is usually as a result of peripheral nerve disorders, which in this case can be spots on the skin numbness, heavy, tingling, weakness of muscles and dry skin disorders due to spending the sweat glands.
Clinical symptoms that occur may include abnormalities in peripheral nerve, skin, hair, muscles, bones, eyes and testes.
1. Abnormalities in peripheral nerve
Abnormalities that occur may include thickening or tenderness due proseskeradangan fibrotic reaction.
The occurrence of peripheral nerves, especially on the trip, close to the surface of the skin al.: Nulnaris mgnus, n. Perouneus lateralis and n. Median.
2. Abnormalities of the skin
Abnormalities that occur may include numbness or macular spots anastetika, nodules, ulcers, ichtiosis, thickening and facies Leonina ear lobe.
3. Abnormalities in hair
Hair loss that occurs is usually limited to mukula or on eyebrows (madarosis)
4. Abnormalities in muscle
The disorder can be a disuse atrophy of muscles that dienervasi by the damaged peripheral nerve al: atrophy of the thenar, hypothenar, M.interosei, M.lumbricalis.
Paralysis of the muscles followed by stiffness of the joints resulting in Claw Hand, foot and drop hand drop.
5. Abnormalities in bone
Can be either osteomyelitis resulting in mutilation.
Can occur res orbsi on bone, especially in the fingers so that the bent tip retracts and is referred to as telescopic finger.
6. Abnormalities in the eye.
Disorders of the eye is often caused by paralysis of m. orbiculris oculi resulting lagopthalmus or eyes can not dipejamkan so that the eye becomes dry due to occur that may progress to keratitis kronea ulcer, iritis, and ended iridosi klitis blindness.
7. Abnormalities of the testis
Can occur orchitis or inflammation of the testes and ends menjaadi atrophy. Testicular atrophy, which results ginekomasti.
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