Cancer Waldenstrom's Macroglobulinemia

Waldenstrom's macroglobulinemia is a cancer that is named after Jan Waldenstrom, Scandinavian doctor who first identified the disease and learn about early 1940. Cancer is a type of non-Hodgkin lymphoma, and is a very rare disease in some papers, which amounts to 1,000 cases and 1,600 are diagnosed with Waldenstrom occur in America each year.

What causes WM, like many other cancers is unknown, but estimates that a change in the DNA may be a cause. Despite this lack of certainty about the causes of Waldenstrom believed to be factors that increase the likelihood of developing the disease. Most cases of Waldenstrom's disease occurring in over 50 years and the average age of incidence is 61 The incidence of the disease are almost twice more for men than women. The condition is inherited which means that those families who have Waldenstrom's or a form of lymphoma is more likely to contract the disease.


An initial diagnosis of Waldenstrom is complex because there are usually no symptoms at first. Usually the first indication of Waldenstrom from routine investigations show atypical results. These inconsistent results could be a high level of IgM in the blood or hyper-viscosity which is another indication of the disease. The diagnosis can also occur if swollen lymph nodes found. It is the same as if a larger than normal spleen or liver was found. A bone marrow biopsy may also be used to diagnose WM.

Waldenstrom's prognosis is very diverse range of victims. Since the disease is very unfrequent was not a huge amount of research to properly assess the survival rate of victims of the disease. International scoring system for predicting Waldenstrom's macroglobulinemia objective is to evaluate the long-term effects of Waldenstrom. Five-nine years is generally accepted that the survival time were diagnosed with Waldenstrom, although the fact that there are very few symptoms, some patients can live with the disease for many years prior to obtaining a diagnosis.

Signs of illness or a problem with the start macroglobulinemia in white blood cells. They cause the cells become abnormal and expansion within the organs or bone marrow and spleen / liver. These complex abnormalities of white blood cells and thus reduce the amount of other blood cells, such as red blood cells. When people have low levels of red blood cells, they suffer from anemia, which causes them to feel weak and drained. Waldenstrom also reduces the amount of healthy white blood cells that reduces the ability of organizations to fight against the flu, bacteria and other infections. These symptoms are not often seen in the early stages of Waldenstrom's disease with most symptoms do not occur until the disease is fairly advanced.

In advanced stages of the disease, the symptoms vary according to the patients. Many of the symptoms are similar to those of non-Hodgkin's lymphoma, which include swollen lymph nodes, fever, fatigue and weight loss, swollen lymph nodes, fever, fatigue and weight loss, swelling of lymph nodes, fever, fatigue and weight loss and swollen lymph nodes, fever, fatigue and weight loss, fatigue, weight loss and lymph nodes, fever, fatigue, and lymph nodes weight loss.

Another symptom is hyper-viscosity or blood clotting occurs due to overproduction causes of Waldenstrom IgM. This causes thickening of blood circulation problems at once and the nervous system. If circulation to the brain is affected, which can cause symptoms similar to stroke. Traffic problems can also lead to Raynaud's phenomenon, which causes a narrowing of blood vessels to slow the flow of blood throughout the body. This can cause circulation to the extremities of human hands and feet, to get cut.